In the latest issue of Empire magazine Spider-Man director Sam Raimi gave a small hint at what villain he would like to see in Spider-Man 4.
“I like it in the Marvel comics when Spider-Man fights Morbius,” said Raimi. “He’s really cool. A vampire! I like that combination of superhero plus supernatural.”
/Film reader Christopher M points out that it might make sense to use him along with The Lizard since both characters “use the same technology but have different animals involved in their research… one having blended with a lizard the other a vampire bat.”
Cramming too many villains into Spider-Man 3 didn’t work that well, so hopefully they will take that into account for the next film.