According to Production Weekly Paul W.S. Anderson will be returning to direct another Resident Evil film. Anderson took the reigns for the first film back in 2002 but decided to take a step back and just write the sequels, opting instead to direct AVP: Alien vs. Predator and Death Race. Resident Evil: Afterlife is scheduled to begin an 8 week shoot starting from September 28th in Toronto, which gives them roughly a year to complete the film as Sony has set the release date for September 17th 2010.
Update: From Shocktillyoudrop:
ShockTillYouDrop.com just talked exclusively to Paul W.S. Anderson, who revealed that Resident Evil: Afterlife will be released in 3D and will kick-off a new trilogy!
Anderson, who will write and direct, told us that the fourth film in the franchise will have the largest budget of all the films so far.
Milla Jovovich will return as Alice in “Afterlife,” opening September 17, 2010. You can also expect some returning characters from the previous films and new characters from the video games.




